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  • Title: [The characteristics of the anticonflict action of fenazepam in rats selected by the method of forced swimming].
    Author: Seredenin SB, Voronina TA, Burlakova EB, Molodavkin GM, Cherniavskaia LI, Khorseva NI, Mdzinarishvili AL.
    Journal: Zh Vyssh Nerv Deiat Im I P Pavlova; 1994; 44(4-5):831-6. PubMed ID: 7810224.
    Abstract:
    A method of classification of outbred albino rats by means of forced swimming in a tank filled with water and equipped by freely turning wheels was developed. Using this technique a population of albino rats can be divided into three groups: highly active (HA), low active (LA) animals, and rats with intermediate activity. HA animals exhibit stable behaviour in forced swimming and conflict situation paradigms. They are also more sensitive to a benzodiazepine anxiolytic phenazepam in conflict situation test. At the same time, LA rats decrease their activity and are less sensitive to phenazepam. Both groups (LA and HA) are not homogeneous: each of them includes animals demonstrating quite another type of behaviour compared with a majority of rats.
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