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  • Title: Association of apolipoprotein E allele epsilon 4 with late-onset sporadic Alzheimer's disease.
    Author: Lucotte G, Visvikis S, Leininger-Müler B, David F, Berriche S, Réveilleau S, Couderc R, Babron MC, Aguillon D, Siest G.
    Journal: Am J Med Genet; 1994 Sep 15; 54(3):286-8. PubMed ID: 7810590.
    Abstract:
    Apolipoprotein E, type epsilon 4 allele (ApoE epsilon 4), is associated with late-onset sporadic Alzheimer's disease (AD) in French patients. The association is highly significant (0.45 AD versus 0.12 controls for epsilon 4 allele frequencies). These data support the involvement of ApoE epsilon 4 allele as a very important risk factor for the clinical expression of AD.
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