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  • Title: Pig kidney (LLC-PK1) cell membrane fluidity during exposure to gentamicin or tobramycin.
    Author: Kohlhepp SJ, Hou L, Gilbert DN.
    Journal: Antimicrob Agents Chemother; 1994 Sep; 38(9):2169-71. PubMed ID: 7811038.
    Abstract:
    The surface membrane properties of LLC-PK1 cells grown with and without various amounts of gentamicin or tobramycin for various lengths of time were determined by measuring the diffusion coefficient of N-(7-nitrobenz-2-oxa-1,3-diazol-4-yl)dipalmitoyl-L- alpha-phosphatidylethanolamine (NBD-PE) and the percentage of NBD-PE free to diffuse after photobleaching. One hour of exposure to tobramycin decreased the percentage that was free to diffuse. After 1 day or longer of exposure to either aminoglycoside the percentage that was free to diffuse returned to preexposure levels and the diffusion coefficient decreased.
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