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  • Title: Sequence of the 5'-flanking region of CYP3A5: comparative analysis with CYP3A4 and CYP3A7.
    Author: Jounaïdi Y, Guzelian PS, Maurel P, Vilarem MJ.
    Journal: Biochem Biophys Res Commun; 1994 Dec 30; 205(3):1741-7. PubMed ID: 7811260.
    Abstract:
    Two genomic clones containing the 3'-end of CYP3A7, the whole 5'-flanking region plus the first exon of CYP3A5 were isolated from two different human genomic banks and sequenced. The 5'-flanking region of CYP3A5, from nucleotide -1 to -1434, was 60% and 59% similar with the corresponding regions of CYP3A4 and CYP3A7, respectively. However, the similarity increased to 74% when regions from nucleotide -1 to -700 were compared and dropped to less than 42% for regions upstream from -700. The CYP3A5 promoter contains a CATA box instead of the typical TATA box and a basic transcription element (BTE). Other consensus sequences previously found in CYP3A4 and CYP3A7 were also identified in the 5'-flanking of CYP3A5 from -1 to -700. Both CYP3A5 and CYP3A7 genes appear to be tandemly associated and transcribed in the same direction on chromosome 7.
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