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  • Title: Clinical meaning of DNA content in the long term behaviour of follicular thyroid tumours: a 12-year follow up.
    Author: Lukács GL, Balázs G, Zs-Nagy I, Mikó T.
    Journal: Eur J Surg; 1994 Aug; 160(8):417-23. PubMed ID: 7811827.
    Abstract:
    OBJECTIVE: To find out if there was any correlation between the DNA aneuploidy in benign tumours and in malignant follicular tumours of the thyroid and the progression of either disease. DESIGN: Retrospective study. SETTING: University hospital. SUBJECTS: 71 of 75 patients who had had cytofluorimetric nuclear DNA analyses done on their follicular thyroid tumours during the period 1977-1980, and for whom clinical follow up data were available. MAIN OUTCOME MEASURES: Correlation between clinical course and finding of aneuploidy in original histological specimens. RESULTS: Aneuploidy was found in 6/40 follicular adenomas, 3/17 adenomatous goitres, and in 13/14 follicular carcinomas. The patients were examined after 12 years, when there had been no recurrences of the benign tumours. 5 of the patients with carcinoma had died of distant metastases, all of whom had aneuploid stemlines. There are, however, 8 patients with carcinomas and aneuploidy who are still alive with no recurrences or metastases. CONCLUSIONS: DNA aneuploidy indicates neither the invasiveness nor the metastatic potential of follicular thyroid tumours, and does not distinguish between the minimally invasive (encapsulated) and highly invasive carcinomas.
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