These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: [Transforming growth factors beta 1 and 2 inhibit proliferation of limbus and corneal epithelium].
    Author: Kruse FE, Tseng SC.
    Journal: Ophthalmologe; 1994 Oct; 91(5):617-23. PubMed ID: 7812093.
    Abstract:
    The role of the various isoforms of transforming growth factor-beta (TGF-beta) concerning the regulation of proliferation, differentiation and wound healing of the corneal epithelium is controversial. We investigated various concentrations of TGF-beta 1 and 2 in a serum-free, defined clonal growth assay concerning the proliferation of limbal and peripheral corneal epithelium. Concentrations between 0.05 and 5.0 ng/ml of either TGF-beta 1 or 2 caused a significant, dose-dependent decrease of both colony formation and colony proliferation in limbal and peripheral corneal epithelial cultures. These results suggest a physiological role for TGF-beta as a negative growth regulator targeting primarily the transient amplifying cells of the limbal and corneal epithelium.
    [Abstract] [Full Text] [Related] [New Search]