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  • Title: 7-OH-DPAT produces place conditioning in rats.
    Author: Mallet PE, Beninger RJ.
    Journal: Eur J Pharmacol; 1994 Aug 22; 261(3):R5-6. PubMed ID: 7813542.
    Abstract:
    The rewarding properties of the putative dopamine D3 receptor-selective agonist, 7-OH-DPAT ((+/-)-2-dipropylamino-7-hydroxy-1,2,3,4- tetrahydronaphthalene hydrobromide), were investigated using a place conditioning paradigm consisting of three phases: preconditioning (three undrugged exposures to an apparatus consisting of two visually distinct compartments); conditioning (four pairings of one compartment with drug); and test (one undrugged exposure to the same apparatus). Rats received either saline, amphetamine (2.0 mg/kg), or 7-OH-DPAT (0.5, 2.0 or 5.0 mg/kg) during conditioning. Amphetamine and 7-OH-DPAT produced a place preference.
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