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  • Title: The Doc transposable element in Drosophila melanogaster and Drosophila simulans: genomic distribution and transcription.
    Author: Vaury C, Chaboissier MC, Drake ME, Lajoinie O, Dastugue B, Pélisson A.
    Journal: Genetica; 1994; 93(1-3):117-24. PubMed ID: 7813908.
    Abstract:
    The mobile element Doc is similar in structure and coding potential to the LINE families found in various organisms. In this paper, we analyze the insertional and structural polymorphism of this element and show that it appears to have a long evolutionary history in the genome of D. melanogaster. Like the family of I elements, the Doc family seems to display three types of elements: full length elements, defective members that have recently transposed and long since immobilized members common to each D. melanogaster strain. These three classes of Doc elements seem to be present in D. simulans, a closely related species to D. melanogaster. Furthermore, we show that Doc is transcribed as a polyadenylated RNA of about 5 kb in length, presumed to be a full length RNA. This transcript is present in different tissues and at different stages of Drosophila development. These results are compared with previous records on the chromosomal distribution of LINEs or other transposable element families. Doc transcription is analyzed in an attempt to understand the link between Doc transcription and transposition.
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