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  • Title: Use of the primed in situ labelling (PRINS) technique for a rapid detection of chromosomes 13, 16, 18, 21, X and Y.
    Author: Pellestor F, Girardet A, Lefort G, Andréo B, Charlieu JP.
    Journal: Hum Genet; 1995 Jan; 95(1):12-7. PubMed ID: 7814017.
    Abstract:
    The primed in situ labelling (PRINS) technique is an alternative to in situ hybridization for chromosomal screening. We have developed a semi-automatic PRINS protocol, using a programmable thermocycler. The method has been successfully tested with specific primers for chromosomes, 13, 16, 18, 21, X and Y. Specific chromosome detection has been obtained on both metaphases and interphase nuclei. This suggests that PRINS may be a reliable technique for detecting aneuploidies and some chromosomal aberrations.
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