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  • Title: Rapid turnover of plasma virions and CD4 lymphocytes in HIV-1 infection.
    Author: Ho DD, Neumann AU, Perelson AS, Chen W, Leonard JM, Markowitz M.
    Journal: Nature; 1995 Jan 12; 373(6510):123-6. PubMed ID: 7816094.
    Abstract:
    Treatment of infected patients with ABT-538, an inhibitor of the protease of human immunodeficiency virus type 1 (HIV-1), causes plasma HIV-1 levels to decrease exponentially (mean half-life, 2.1 +/- 0.4 days) and CD4 lymphocyte counts to rise substantially. Minimum estimates of HIV-1 production and clearance and of CD4 lymphocyte turnover indicate that replication of HIV-1 in vivo is continuous and highly productive, driving the rapid turnover of CD4 lymphocytes.
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