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  • Title: Effects of chloroquine on pentylenetetrazol-induced convulsions in mice.
    Author: N'Gouemo P, Ben Attia M, Belaidi M.
    Journal: Pharmacol Res; 1994; 30(2):99-103. PubMed ID: 7816747.
    Abstract:
    The effects of chloroquine pretreatment were investigated on pentylenetetrazol-induced clonic-tonic convulsions in mice. The results demonstrated that lower doses of chloroquine (1.0-5.0 mg kg-1) significantly induced a delay in onset time to the clonic component of convulsions and reduced the incidence of the tonic phase of convulsions and mortality. In contrast, at a higher dose range (10.0-50.0 mg kg-1) chloroquine had opposite effects. This study points out the biphasic action of chloroquine on clonic-tonic PTZ convulsions and its preferential effect against the tonic phase of convulsions.
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