These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: Nitrogen microbubbles induce a disappearance of single platelets (aggregation) with porcine platelets: a comparative study of the effects of anticoagulants and blood collection methods.
    Author: Søfteland E, Framstad T, Nordvik A, Strand I, Thorsen T, Holmsen H.
    Journal: Thromb Res; 1994 Oct 01; 76(1):61-70. PubMed ID: 7817361.
    Abstract:
    The pathogenesis of decompression illness (DCI) is uncertain. DCI involves all parts of the organism where gas bubbles are produced. They have both primary and secondary effects and have been classified as an agonist aggregating human platelets. In vitro effects of N2 bubbles on porcine platelets were investigated. Comparative studies using two different anticoagulants and three different sampling methods were performed. A disappearance of single platelets interpreted as platelet aggregation was observed in the presence of N2 bubbles in all studied groups. Aggregatory responses were more profound with platelets in heparinized plasma than in citrated plasma. In citrated plasma the aggregatory responses were more profound when blood was obtained from nonanaesthetized (awake) animals than from slaugtherhouse animals. Adrenaline (1 microM) had an inhibitory effect on N2 bubble induced platelet aggregation in vitro. The pig could be useful to investigate possible gas bubble effects in vivo.
    [Abstract] [Full Text] [Related] [New Search]