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  • Title: Translational control of GCN4: an in vivo barometer of initiation-factor activity.
    Author: Hinnebusch AG.
    Journal: Trends Biochem Sci; 1994 Oct; 19(10):409-14. PubMed ID: 7817398.
    Abstract:
    Phosphorylation of translation initiation factor-2 (eIF-2) is an adaptive mechanism for downregulating protein synthesis under conditions of starvation and stress. The yeast Saccharomyces has evolved a sophisticated means of increasing translation of GCN4 mRNA when eIF-2 is phosphorylated, allowing the induction of an important stress-response protein when expression of most other genes is decreasing. Because translation of GCN4 mRNA is so tightly coupled to eIF-2 activity, genetic analysis of this system has provided unexpected insights into the regulation of eIF-2 and its guanine nucleotide exchange factor, eIF-2B.
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