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  • Title: A comparative study of daily and twice-weekly continuation regimens of tuberculosis chemotherapy, including a comparison of two durations of sanatorium treatment.
    Journal: Tubercle; 1976 Mar; 57(1):45-8. PubMed ID: 781965.
    Abstract:
    Further results are presented of a controlled clinical trial carried out in Czechoslovakia of chemotherapeutic regimens in pulmonary tuberculosis in which, following 3 months of standard triple chemotherapy, 3 continuation regimens allocated at random for up to 18 or 24 months were compared. These were PAS plus isoniazid daily, streptomycin plus isoniazid twice a week and streptomycin plus isoniazid twice a week up to 1 year and then streptomycin plus isoniazid once a week. After 3 years the results of all 3 continuation regimens were highly satisfactory and it was concluded that they were equally effective, but that the intermittent regimens have the advantage of stricter control over the patient's chemotherapy.
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