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  • Title: Nuclear presence of two lysosomal enzymes in rat implantation sites.
    Author: Duran-Reyes G, Diaz-Flores M, Castillo S, Hicks JJ.
    Journal: Int J Fertil Menopausal Stud; 1994; 39(5):299-303. PubMed ID: 7820164.
    Abstract:
    OBJECTIVE: To test the Szego hypothesis of increased beta-glucuronidase and acid phosphatase activities in hormone target tissues. METHODS: The presence of beta-glucuronidase and acid phosphatase activities in nuclear subcellular fractions obtained from decidual (implantation site) and stromal (nonimplantation zone) tissues was demonstrated by both biochemical measurements and ultramicrographic analysis utilizing a histochemical reaction. RESULTS: Acid phosphatase was almost twice as abundant in nuclei and lysosomes of epithelial cells (implantation sites), and beta-glucuronidase also was significantly more active in nuclei from epithelial and decidual tissues than in nonimplantation tissue. CONCLUSION: Our results, utilizing the implantation process as experimental model, support the Szego hypothesis of the lysosomal role in hormonal mechanisms of action.
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