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  • Title: [Effect of the tranquilizer gidazepam on the behavioral reactions of rats in the first weeks after resuscitation].
    Author: Mutuskina EA, Garibova TL, Zarzhetskiĭ IuV, Maula M, Voronina TA, Gurvich AM.
    Journal: Patol Fiziol Eksp Ter; 1994; (3):10-2. PubMed ID: 7824332.
    Abstract:
    The experiments have indicated that the first week of postresuscitation is marked by enhanced goal-investigating behaviour in the open field, by the accelerated learning of an operant reflex, and by decreased anxiety in the conflict situation test in male rats undergone a 10-min arrest of systemic circulation. There was a depressive behavior in the open field following 6-8 weeks with the normalization of operant reflex learning and the level of anxiety in the conflict test situation. Gidazepam (3 mg/kg, i.p.) produced a sedative effect in the first week after resuscitation, then 6-8 weeks later it displayed its anxiolytic and activating effect which is similar to this dose of the agent given to intact animals. The findings suggest that there are changes in the pattern of neurophysiological abnormalities, as well as a response of the benzodiazepine receptor complex to drugs during a resuscitative process, which may be one of the components of formation of a post-resuscitative central nervous abnormality.
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