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  • Title: [Analysis of cellular and humoral mechanisms of the anti-radiation action of the drug HC-1539].
    Author: Lebedev VG, Vorotnikova TV, Deshevoĭ IuB.
    Journal: Patol Fiziol Eksp Ter; 1994; (3):20-2. PubMed ID: 7824336.
    Abstract:
    The agent HC-1539, an analogue of tamoxifen, was studied for its effects on the blood system of intact animals and on the time course of postradiation recovery of hemopoiesis. HC-1539 given to the mice unexposed to radiation reduced bone marrow levels of CFUs (a colony of forming units in the spleen) and CFU-GM (that in the granulocyte-macrophages) and increased splenic counts of granulocyte-macrophage precursors. There was also a decrease in the proliferative activity of CFU-GM 1 and 5 days after the drug administration and an increase in serum GM-CCP levels when the agent showed the peak of its radioprotective effect. In the HC-1539-treated mice, there was a more intensive normalization of the CFUs of CFU-GM myeloid and erythroid hemopoietic populations than in the radiation-exposed ones. Thus, the mechanisms responsible for the radioprotective action of HC-1539 may be associated both with its direct effects on the proliferation and differentiation of hemopoietic cellular precursors and with the stimulation of release of growth-differential factors by hemopoietic microenvironmental elements.
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