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  • Title: The brain tryptophan hydroxylase activity in the sleep-like states in frog.
    Author: Kulikov AV, Karmanova IG, Kozlachkova EY, Voronova IP, Popova NK.
    Journal: Pharmacol Biochem Behav; 1994 Oct; 49(2):277-9. PubMed ID: 7824538.
    Abstract:
    The activity of the rate-limiting enzyme of serotonin biosynthesis, tryptophan hydroxylase, was determined in the brain stem in active awake frogs, and frogs in three sleep-like states: with plastic muscle tone (SLS-1), with rigid muscle tone (SLS-2), and with relaxed muscle tone (SLS-3). Significant decrease in the enzyme activity has been found in frogs in SLS-1 and SLS-2 compared to awake animals. The development in frogs a cataleptic-like immobility after treating the animals with rhythmic lighting was accompanied with a decrease in the brain tryptophan hydroxylase activity. These results provide strong evidence for the involvement of the brain serotonin in frogs in the control of evolutionary ancient sleep-like states, probably by the regulation of muscle tone.
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