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  • Title: PD135158, a CCK-B antagonist, reduces "state," but not "trait" anxiety in mice.
    Author: Belzung C, Pineau N, Beuzen A, Misslin R.
    Journal: Pharmacol Biochem Behav; 1994 Oct; 49(2):433-6. PubMed ID: 7824561.
    Abstract:
    It has recently been proposed that Balb/c neophobic responses in a free exploratory paradigm are related to "trait" anxiety, while the behavior of mice in the light/dark choice test paradigm is related to "state" anxiety. The purpose of this study was to assess the action of the CCK-B receptor antagonist PD135158 in both models. Results show that PD135158 was effective in the light/dark choice test but not on the Balb/c neophobic reactions in the free exploratory situation. It is suggested that PD135158 is specially effective in state anxiety induced by fear provoking situations.
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