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  • Title: Prednisone and azathioprine compared to prednisone plus low-dose azathioprine and cyclophosphamide in the treatment of diffuse lupus nephritis.
    Author: Ginzler E, Diamond H, Guttadauria M, Kaplan D.
    Journal: Arthritis Rheum; 1976; 19(4):693-9. PubMed ID: 782464.
    Abstract:
    A 1-year double-blind crossover study comparing prednisone and azathioprine to prednisone plus low-dose azathioprine and cyclophosphamide was carried out in 14 patients with diffuse lupus nephritis. Low-dose triple therapy had no apparent therapeutic advantage over prednisone plus azathioprine. Cyclophosphamide-induced ovarian failure and hematuria were not avoided by its use in low dose.
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