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  • Title: Bronchodilator activity of theophylline derivatives substituted at the 7-position.
    Author: Corsano S, Scapicchi R, Strappaghetti G.
    Journal: Arch Pharm (Weinheim); 1994 Oct; 327(10):631-5. PubMed ID: 7826198.
    Abstract:
    Theophylline derivatives with several groups linked at the 7-position were synthesized and their pharmacological activities were studied on guinea pig. Relaxant action in the tracheal muscle was increased in comparison with that of theophylline when the 3(2H)-pyridazinone system was linked to 7-(2-ethyl)-theophylline through the piperazine ring, but decreased when the 7-(2-ethyl)-theophylline was linked to 3(2H)-pyridazinone ring through an amino group.
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