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  • Title: [Synthesis and comparative analysis of antigenic activity of peptides from hypervariable region V3 of human immunodeficiency virus I gp120 surface glycoprotein].
    Author: Semiletov IuA, Rzhaninova AA, Garaev MM.
    Journal: Bioorg Khim; 1994 Oct; 20(10):1070-9. PubMed ID: 7826406.
    Abstract:
    A set of peptides (amino acid positions 10-23) corresponding to seven most widely spread variants of the gp120 V3 domain in the HIV-infected population of South Russia were prepared by the solid-phase synthesis. A laboratory variant of the indirect enzyme-linked immunosorbent assay (ELISA) was developed for the determination of V3 specific antibodies with use of the peptides synthesized. The analysis of the V3-specific antibodies in HIV-infected using the elaborated test-system revealed a correlation between the V3 variants distribution and the occurrence of antibodies against these variants.
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