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  • Title: Effects of zotepine, haloperidol and clozapine on MK-801-induced stereotypy and locomotion in rats.
    Author: Gattaz WF, Schummer B, Behrens S.
    Journal: J Neural Transm Gen Sect; 1994; 96(3):227-32. PubMed ID: 7826573.
    Abstract:
    In the present study we compared the effects of the atypical neuroleptic zotepine to haloperidol and clozapine on stereotypies and locomotion induced in rats by the N-methyl-D-aspartate (NMDA) antagonist MK-801. Zotepine caused a dose-dependent reduction of MK-801-induced stereotypies and locomotion. Zotepine at a dosis of 2.5 mg/kg body weight showed a similar effect to 0.25 mg/kg haloperidol in reducing stereotypies and locomotion. Clozapine (5.0 mg/kg) reduced significantly locomotion and non-significantly stereotypies. These results add support to the assumption that MK-801-induced behavior provides an adequate animal model to test the potential efficacy of typical and atypical neuroleptics in the treatment of psychoses.
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