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  • Title: Regulation of gene expression by transcription factors Ets-1 and Ets-2.
    Author: Tymms MJ, Kola I.
    Journal: Mol Reprod Dev; 1994 Oct; 39(2):208-14. PubMed ID: 7826624.
    Abstract:
    The ETS family of transcription factors have a DNA-binding domain in common that binds a core GGA(A/T) DNA sequence. A large number of proteins have now been identified that contain an ETS DNA-binding domain (see review by Wasylyk et al., 1993). Ets-1 was first described as the cellular homolog of v-ets. which is translated as a 135-kDa gag-myb-ets fusion protein from the replication-deficient retrovirus E26 in chickens. Ets-2 was subsequently described as a closely related protein that contains the highly conserved ETS DNA-binding domain. This paper considers the manner by which the two closely related genes, Ets-1 and Ets-2, apparently play distinct roles in embryo development and in the immune system of adult mice. Although both Ets-1 and Ets-2 transform fibroblasts (Seth et al., 1989), the temporal and tissue-specific expression patterns suggest that these two proteins play distinct biological roles and consequently transactivate different downstream cellular target genes.
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