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  • Title: High density lipoprotein inhibits platelet 12-lipoxygenase activity.
    Author: Fujimoto Y, Tsunomori M, Muta E, Yamamoto T, Nishida H, Sakuma S, Fujita T.
    Journal: Res Commun Mol Pathol Pharmacol; 1994 Sep; 85(3):355-8. PubMed ID: 7827811.
    Abstract:
    The effects of high density lipoprotein (HDL) and low density lipoprotein (LDL) on the formation of 12-hydroxy-5,8,10,14-eicosatetraenoic acid (12-HETE), thromboxane (TX) B2 and 12-hydroxy-5,8,10-heptadecatrienoic acid (HHT) in washed rabbit platelets were examined. HDL had a powerful inhibitory effect on 12-HETE formation, while it produced only a small increase in TXB2 and HHT formation. LDL did not affect the formation of 12-HETE, TXB2 and HHT. These results suggest that HDL is a selective inhibitor of platelet 12-lipoxygenase and may play a protective role in atherogenesis by preventing the generation of 12-HETE.
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