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  • Title: Adipocyte alpha 2A-adrenoceptor is the only alpha 2-adrenoceptor regulated by testosterone.
    Author: Bouloumié A, Valet P, Daviaud D, Prats H, Lafontan M, Saulnier-Blache JS.
    Journal: Eur J Pharmacol; 1994 Sep 15; 269(1):95-103. PubMed ID: 7828661.
    Abstract:
    The effects of chronic administration of testosterone on alpha 2-adrenoceptor expression in male hamsters were investigated in order to explore the selectivity of testosterone regulation towards the alpha 2-adrenoceptor subtypes. A homogeneous population of alpha 2-adrenoceptors was identified with [3H]RX821002 binding in adipocytes, colocytes and liver, whereas the alpha 2-adrenoceptor sites identified in kidney and brain were heterogeneous. Competition studies with alpha 2-adrenoceptor ligands characterized the presence of the alpha 2A-adrenoceptor subtype in adipocytes, colocytes, kidney and brain homogenates and of the alpha 2B-adrenoceptor subtype in kidney and liver. RNase protection assay with a selective hamster alpha 2A-adrenoceptor cRNA probe confirmed the expression of alpha 2A-adrenoceptor mRNA in adipocytes, colocytes, kidney and brain. Testosterone treatment did not modify the alpha 2-adrenoceptor densities whatever the subtype, except for the adipocyte alpha 2A-adrenoceptor, which was significantly increased. These results demonstrate that testosterone only up-regulates the adipocyte alpha 2A-adrenoceptor.
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