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  • Title: Criteria in the evaluation of live intranasal influenza virus vaccines.
    Author: Zygraich N.
    Journal: Dev Biol Stand; 1976; 33():141-50. PubMed ID: 782962.
    Abstract:
    Live influenza virus vaccines should meet the following criteria: attenuation, immunogenicity, lack of spread, genetic stability, production in a suitable cell substrate, and stability during storage. In addition, they should be able to induce a wide antigenic protection. These various aspects will be discussed with reference to the "Alice" strain of live influenza A virus, which possesses all the properties for a good live attenuated virus vaccine.
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