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  • Title: A new semisynthetic macrolide antibiotic 3-O-oleandrosyl-5-O-desosaminylerythronolide A oxime.
    Author: LeMahieu RA, Ax HA, Blount JF, Carson M, Despreaux CW, Pruess DL, Scannell JP, Weiss F, Kierstead RW.
    Journal: J Antibiot (Tokyo); 1976 Jul; 29(7):729-34. PubMed ID: 783104.
    Abstract:
    A new antibiotic, 3-O-oleandrosyl-5-O-desosaminylerythronolide A oxime (3) was produced from erythronolide A oxime (1) by the oleandomycin-producing culture, Streptomyces antibioticus ATCC 11891. The structure of 3 was determined by degradative studies and confirmed by X-ray analysis. Compound 3 was found to be less active, but more stable to acid, then erythromycin A oxime.
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