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  • Title: [Clinical evaluation on ofloxacin administered once daily in the treatment of acute uncomplicated cystitis].
    Author: Okuyama A, Miki T, Kokado Y, Fujioka H, Kuroda H, Takatera H, Yasunaga Y, Kishimoto T, Yamada R, Oda M.
    Journal: Hinyokika Kiyo; 1994 Nov; 40(11):1041-7. PubMed ID: 7832079.
    Abstract:
    A comparative study of ofloxacin (OFLX), a new oral quinolone, was carried out at the Department of Urology, Osaka University Hospital and its eighteen affiliated hospitals to evaluate the clinical efficacy and safety of daily dose of 300 mg, given either once daily dose (SID group), or in three divided doses (TID group), in the treatment of acute uncomplicated cystitis in women. Clinical efficacy was evaluated in 42 cases from the SID group, and 43 cases from TID group, respectively, according to the criteria by the Japanese UTI Committee. In the SID group, the clinical efficacy was evaluated as excellent in 29 cases, moderate in 12 and poor in 1, with an overall clinical effectiveness rate of 98%. In the TID group, it was evaluated as excellent in 25 cases, moderate in 17 and poor in 1, with an overall clinical effectiveness rate of 98%. Safety was monitored only by subjective complaints. In the SID group, no subjective side effects appeared (0%). In the TID group, one of the 43 women (2.3%) complained of borborygmus. These findings suggest that there was no significant difference between the two groups in the safety and efficacy of ofloxacin.
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