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  • Title: Regulation of sex-hormone-binding globulin production by endogenous estrogens in vitro.
    Author: Loukovaara M, Carson M, Adlercreutz H.
    Journal: Biochem Biophys Res Commun; 1995 Jan 26; 206(3):895-901. PubMed ID: 7832802.
    Abstract:
    The effect of endogenous estrogens on sex-hormone-binding globulin (SHBG) production was studied in HepG2 cells. 17 beta-estradiol, estrone, and estrogens from both 2- and 16 alpha-hydroxylative pathways stimulated SHBG production, but not in parallel with their binding affinities for the estrogen receptor. Thus, the underlying mechanism may be other than a pure interaction with the estrogen receptor.
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