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  • Title: Tumor-suppressor gene products in cell contacts: the cadherin-APC-armadillo connection.
    Author: Hülsken J, Behrens J, Birchmeier W.
    Journal: Curr Opin Cell Biol; 1994 Oct; 6(5):711-6. PubMed ID: 7833051.
    Abstract:
    Various structural components of intercellular junctions have recently been found to represent (or be related to) products of tumor-suppressor genes. The tumor-suppressor gene product adenomatous polyposis coli (APC) binds to beta 2-catenin (homologous to the product of Drosophila armadillo), which is cytoplasmically associated with the cell adhesion molecule E-cadherin.
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