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  • Title: Sterols stabilize the ripple phase structure in dihexadecylphosphatidylcholine.
    Author: Cunningham BA, Midmore L, Kucuk O, Lis LJ, Westerman MP, Bras W, Wolfe DH, Quinn PJ, Qadri SB.
    Journal: Biochim Biophys Acta; 1995 Jan 26; 1233(1):75-83. PubMed ID: 7833353.
    Abstract:
    The presence of various sterols in mixtures with dihexadecylphosphatidylcholine (DHPC) was studied using static X-ray diffraction of temperature equilibrated samples, and real-time X-ray diffraction of samples undergoing temperature scans. It was found that these sterols eliminate the interdigitation of the alkyl chains in the DHPC sub-gel and gel-state bilayers while stabilizing the ripple gel-state at the expense of the gel-state bilayer phase. The ripple-ripple phase transition previously observed for dipalmitoylphosphatidylcholine in the presence of low molar concentrations of sterols (Wolfe et al. (1992) Phys. Rev. Lett. 68, 1085-1088) was also observed for similar DHPC-sterol mixtures. In addition, we show the first evidence that the presence of 5 alpha-cholestane-3 beta,5,6 beta-triol will cause the lipid mixtures to continue to adopt a ripple mesophase structure even after the DHPC alkyl chain becomes disordered.
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