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  • Title: Vitamin A ameliorates the genotoxicity in mice of aflatoxin B1-containing Aspergillus flavus infested food.
    Author: Sinha SP, Dharmshila K.
    Journal: Cytobios; 1994; 79(317):85-95. PubMed ID: 7835072.
    Abstract:
    Young weaning Swiss albino mice were orally administered crude aflatoxin B1 in a dose mimicking human exposure condition, i.e. at 0.05 micrograms/kg body weight/day for 14 weeks. Vitamin A (retinol) was orally administered along with the toxin in double (132 IU/kg body wt/day) the human equivalent therapeutic dose. The results suggested that vitamin A minimised the frequency of toxin-induced clastogeny in both mitotic and meiotic chromosomes. The decreases in sperm count as well as increases in abnormality in the gross morphology of the sperm-head, as observed upon toxin treatment, was ameliorated by the vitamin A.
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