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  • Title: Further evidence that the tachycardiac response to 5-hydroxytryptamine in rats is not mediated via typical 5-HT2 receptors.
    Author: Krstić MK, Katusić ZS.
    Journal: Gen Pharmacol; 1994 Sep; 25(5):917-21. PubMed ID: 7835637.
    Abstract:
    1. In pithed rats, the receptor type of cardiac tissue mediating the tachycardiac response to 5-hydroxytryptamine (5-HT) was analysed. 2. Ketanserin, mesulergine and methiothepin, administered in doses which antagonized the pressor response to 5-HT, slightly reduced, considerably reduced and antagonized, respectively, its tachycardiac response. 3. 8-OH DPAT and RU 24969 produced no significant tachycardia, while DOI neither mimicked nor blocked the 5-HT-induced tachycardia. 4. The tachycardia was not affected by MDL 72222, metoclopramide and cocaine. 5. The hypothesis is proposed that in rats the tachycardiac response to 5-HT is mediated via 5-HT receptors belonging to an yet unclassified subtype of 5-HT1 or 5-HT2 receptors.
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