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  • Title: [Single dose toxicity study of lactitol (NS-4) in dogs].
    Author: Nagata R, Onishi M, Okasaki K, Hamasu Y, Sumi N.
    Journal: J Toxicol Sci; 1994 Nov; 19 Suppl 3():301-4. PubMed ID: 7837292.
    Abstract:
    Male beagle dogs were orally given lactitol, a hepatic encephalopathy drug, in a single dose of 7.5, 15.0 or 30.0 g/kg. Vomiting was seen within 30 minutes after dosing in all treated groups. Diarrhea was observed 3 or 5 hours after dosing in the 15.0 and 30.0 g/kg dose groups. There were no drug related effects on survival, food and water consumption, body weight gain or tissues and organs.
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