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  • Title: Immune response to influenza vaccination of elderly people. A randomized double-blind placebo-controlled trial.
    Author: Govaert TM, Sprenger MJ, Dinant GJ, Aretz K, Masurel N, Knottnerus JA.
    Journal: Vaccine; 1994 Oct; 12(13):1185-9. PubMed ID: 7839722.
    Abstract:
    The objective of this study was to determine the immune response to influenza vaccination in elderly people, using a randomized, double-blind, placebo-controlled trial. Venous blood was taken from 1838 people aged 60 years and older, prior to injection with the influenza vaccine or a placebo. A second blood sample was taken three weeks later. The antibody reaction was measured by comparing the geometric mean titre and the percentage of participants who had a protective antibody titre before and after vaccination and for all sera of each strain. A protective antibody titre was found in 43-68% of those who had received the vaccine, depending on the strain investigated. Patients potentially at risk showed a response similar to the other participants. We conclude that influenza vaccination in elderly people provides a reasonable to good immune response. Research is needed on whether a good immune response decreases the incidence of influenza.
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