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  • Title: HIV seropositivity in Nigerians with lymphoproliferative malignancies.
    Author: Okpala IE, Shokunbi WA, Saliu I, Akinboye DO, Essien EM.
    Journal: Afr J Med Med Sci; 1993 Dec; 22(4):73-6. PubMed ID: 7839934.
    Abstract:
    One hundred and four Nigerians with lymphoproliferative malignancies were tested for antibodies to human immunodeficiency virus types 1 and 2 (HIV-1 and 2). All the patients with high grade lymphomas in this series were seronegative for HIV-1 and 2. Only 1 of the 104 patients had antibody to HIV-1 and none had antibody to HIV-2. Although the single positive result would suggest a higher HIV-1 seropositivity rate among the patients compared with the general Nigerian population, it should be interpreted with caution. This preliminary data emphasizes the need for an urgent countrywide study of the problem among this category of patients in Nigeria in view of the low prevalence rate of HIV-1 and 2 in the country. Several workers have reported an association between lymphoproliferative malignancies and HIV infection. The revised diagnostic criteria for AIDS which include HIV-seropositivity in patients with Non-Hodgkin's lymphoma of the small, noncleaved, immunoblastic and large cell types are consistent with the observed relationship between HIV infection and lymphoproliferative malignancies. Following this revised definition, it was deemed necessary to determine the prevalence of HIV infection among the patients with lymphoproliferative malignancies seen in the University College Hospital, Ibadan, Nigeria. 104 newly-diagnosed Nigerian patients with lymphoproliferative malignancies seen at the hospital between December 1986 to May 1990 were tested for antibodies to HIV-1 and HIV-2. One patient was HIV-1-seropositive and none were HIV-2-seropositive. All patients with high-grade lymphomas were seronegative for both viruses. These preliminary data indicate the urgent need for a countrywide study designed to learn more about the relationship between HIV infection and lymphoid malignancies in Nigeria. The authors stress that while Burkitt's lymphoma coexisting with HIV-seropositivity is currently taken as diagnostic of AIDS, it is important to establish that the viral infection was acquired before the tumor developed in each patient. This observation is important due to the commonality of Burkitt's lymphoma in Nigeria where some hospitals are still unable to screen blood for HIV before transfusion.
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