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  • Title: [Compensating for acidosis: pro].
    Author: Hörnchen U.
    Journal: Anasthesiol Intensivmed Notfallmed Schmerzther; 1994 Dec; 29(8):501-5. PubMed ID: 7841277.
    Abstract:
    New insights about the pathophysiology of acidosis as well as the efficacy of various buffer solutions have once again started the discussion about the necessity and indications of buffer therapy. After evaluation of the current literature one has to conclude that the spectrum of indications for application of buffer solution is remarkably small; some indications, however, remain well accepted. It has been shown that acidosis with pH-values above 7.2 has to be buffered only rarely, especially if the underlying disease responds to causal therapy. pH-values under 7.2, however, caused by renal tubular acidosis or by certain types of lactate acidosis, respond to buffer therapy. The choice of buffer solution depends on the pathophysiology of the underlying disease. In particular the application of CO2 generating buffer solutions under the conditions of critically reduced circulation and ventilation remains doubtful. Application of CO2 generating buffers seems to be justified only if intracellular acidosis can be prevented by immediate elimination of carbon dioxide generated by the buffer reaction.
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