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  • Title: Early diagnosis of optic glioma in children with neurofibromatosis type 1.
    Author: Rossi LN, Pastorino G, Scotti G, Gazocchi M, Maninetti MM, Zanolini C, Chiodi A.
    Journal: Childs Nerv Syst; 1994 Sep; 10(7):426-9. PubMed ID: 7842431.
    Abstract:
    Twenty-five asymptomatic patients with neurofibromatosis type 1 (NF 1), aged 6-21 years, underwent the following examinations: intracranial magnetic resonance testing (MRI), visual acuity testing, ophthalmoscopy, and visual field and pattern reversal visual evoked potentials (VEPs). MRI showed enlargement of one or both optic nerves in six children, with bilateral involvement in three. VEPs were normal in all these patients; two of them had abnormalities on other visual examinations, although there were no subjective visual disturbances. These results show that VEPs cannot be considered as a screening test for optic pathway lesions in children with NF 1, as previously stated, and that other types of visual function examination may be more sensitive. These data may contribute to the establishment of more precise guidelines for the evaluation and treatment of children with NF 1.
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