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  • Title: L-dopa-induced air-stepping in preweanling rats. I. Effects of dose and age.
    Author: McCrea AE, Stehouwer DJ, Van Hartesveldt C.
    Journal: Brain Res Dev Brain Res; 1994 Oct 14; 82(1-2):136-42. PubMed ID: 7842501.
    Abstract:
    The effects of several doses of L-DOPA (25, 50, 75 and 100 mg/kg) on air-stepping were studied in rats on the day of birth and on 5, 10, 15 and 20 days of age. Occurrence of air-stepping increased and latency to air-stepping generally decreased with dose except at 10 days of age; duration of air-stepping increased with increasing dose of L-DOPA at every age. The occurrence of a variety of air-stepping gaits was age-dependent. On the day of birth, air-stepping consisted primarily of episodes of forelimb alternation; on days 5-20, diagonal progression was the predominant gait, but beginning at day 10, episodes of air-swimming, air-galloping and other locomotor patterns were interspersed. Not only could the durations of most of these gaits be increased with increasing dose of L-DOPA, but at some ages, increasing the dose of L-DOPA led to gait changes.
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