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  • Title: Possible involvement of the transcription factor ISGF3 gamma in virus-induced expression of the IFN-beta gene.
    Author: Kawakami T, Matsumoto M, Sato M, Harada H, Taniguchi T, Kitagawa M.
    Journal: FEBS Lett; 1995 Jan 30; 358(3):225-9. PubMed ID: 7843405.
    Abstract:
    Two virus-inducible transcription factors, IRF-1 and IRF-2 have been identified as an activator and a repressor, respectively, of the type I interferon (IFN) genes. Recent studies with mice carrying null mutations for the IRF-1 or IRF-2 alleles have revealed the existence of IRF-1-dependent and -independent pathways mediating IFN-beta gene induction. Here we report that the expression of an IRF family member ISGF3 gamma is induced upon viral infection in IRF-1-/-, IRF-2-/- embryonic fibroblasts. Furthermore, ISGF3 gamma can bind to a virus-inducible promoter element in the IFN-beta gene. These results suggest that ISGF3 gamma or complex containing ISGF3 gamma is involved in the IRF-1-independent pathway mediating IFN-beta gene regulation.
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