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  • Title: Isolation and characterization of a new 12-membered macrolide FD-895.
    Author: Seki-Asano M, Okazaki T, Yamagishi M, Sakai N, Takayama Y, Hanada K, Morimoto S, Takatsuki A, Mizoue K.
    Journal: J Antibiot (Tokyo); 1994 Dec; 47(12):1395-401. PubMed ID: 7844034.
    Abstract:
    During the course of our screening program for natural product drugs effective against multidrug resistant cells by using adriamycin resistant HL-60 cells, we have discovered a new 12 membered macrolide FD-895 in the fermentation broth of Streptomyces hygroscopicus A-9561 isolated from a soil sample collected at Iriomote Island, Okinawa prefecture, Japan. FD-895 showed stronger cytocidal activities against in vitro tumor cell lines than adriamycin. FD-895 had the same IC50 values against parent and adriamycin resistant HL-60 cells.
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