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  • Title: Directed biosynthesis of 5"-fluoropactamycin in Streptomyces pactum.
    Author: Adams ES, Rinehart KL.
    Journal: J Antibiot (Tokyo); 1994 Dec; 47(12):1456-65. PubMed ID: 7844040.
    Abstract:
    A new pactamycin analogue, 5"-fluoropactamycin, was prepared by directed biosynthesis. Supplementation of the fermentation medium of Streptomyces pactum, var. pactum with 3-amino-5-fluorobenzoic acid, an analogue of 3-aminobenzoic acid, an advanced precursor in pactamycin biosynthesis, resulted in co-production of pactamycin and the new pactamycin analogue. A similar feeding experiment with 3-amino-5-methylbenzoic acid did not result in formation of the corresponding methylated pactamycin analogue, but only in inhibition of pactamycin production. Comparison of antimicrobial and cytotoxic activities of pactamycin and 5"-fluoropactamycin showed no significant differences.
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