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  • Title: Evaluation of specific Fasciola antigen in the immunodiagnosis of human fascioliasis in Egypt.
    Author: Shaker ZA, Demerdash ZA, Mansour WA, Hassanein HI, el Baz HG, el Gindy HI.
    Journal: J Egypt Soc Parasitol; 1994 Dec; 24(3):463-70. PubMed ID: 7844410.
    Abstract:
    Enzyme-linked immunosorbent assay (ELISA) and enzyme linked immunoelectrotransfer blot technique (EITB) were employed for the detection of circulating Fasciola antibodies in infected human sera using a specific Fasciola antigen, prepared by immunoaffinity purification of homogenates of Fasciola hepatica adult worms. Ninety two individuals diagnosed clinically and parasitologically were classified into: Fascioliasis group (21 patients), schistosomiasis group (21 patients) and subjects harbouring other parasitic infections (50 patients). Eighteen healthy individuals served as normal controls. ELISA was 100% sensitive and 93% specific with 96.5% diagnostic efficacy, whereas EITB was 100% sensitive and specific with 100% diagnostic efficacy. Our data revealed that ELISA can be used as a good screening test while EITB can serve as a confirmatory test for immunodiagnosis of fascioliasis.
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