These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: The stability of anticonvulsant drugs in whole blood.
    Author: Chetty M.
    Journal: Ther Drug Monit; 1994 Oct; 16(5):491-4. PubMed ID: 7846747.
    Abstract:
    The stability of four commonly used anticonvulsant drugs, viz., valproic acid, carbamazepine, phenytoin, and phenobarbital in whole blood was investigated after storage at conditions simulating storage and transport from outlying rural clinics. Storage conditions included 24 h at 23-25 degrees C, 24 h at 37 degrees C, 48 h at 37 degrees C, and 48 h at 23-25 degrees C. Valproic acid, carbamazepine, and phenobarbital were stable for 48 h at both storage temperatures. Phenytoin was stable at 23-25 degrees C for 48 h. However, small but statistically significant decreases in phenytoin concentrations were observed in samples that were stored for 24 h or longer at 37 degrees C. These changes may not be clinically significant.
    [Abstract] [Full Text] [Related] [New Search]