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  • Title: Direct antiproliferative effect of triptorelin on human breast cancer cells.
    Author: Marini L, Iacopino F, Schinzari G, Robustelli della Cuna FS, Mantovani G, Sica G.
    Journal: Anticancer Res; 1994; 14(5A):1881-5. PubMed ID: 7847821.
    Abstract:
    We investigated the effect of Triptorelin (Decapeptyl, DEC) alone or combined with Tamoxifen (TAM) or Medroxyprogesterone acetate (MPA) in human breast cancer cells. DEC did not affect the growth of estrogen-insensitive MDA-MB-231 cells, while it inhibited the estrogen-stimulated proliferation of MCF-7 and CG-5 cells. No amplification of growth inhibition induced by TAM or MPA was determined by DEC. Progesterone receptor levels of CG-5 cells were significantly enhanced by DEC in the presence of 17 beta-estradiol (E2) with respect to those in control and E2-treated cells.
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