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  • Title: Concentrations of amyloid beta protein in cerebrospinal fluid of patients with Alzheimer's disease.
    Author: van Gool WA, Kuiper MA, Walstra GJ, Wolters EC, Bolhuis PA.
    Journal: Ann Neurol; 1995 Feb; 37(2):277-9. PubMed ID: 7847870.
    Abstract:
    Deposition of fibrillar amyloid beta protein (A beta) is increased in brains of patients with Alzheimer's disease. Concentrations of A beta were measured in cerebrospinal fluid with an enzyme-linked immunosorbent assay in 10 neurological patients free from neurodegenerative disease, 28 patients with Parkinson's disease, and 18 patients with probable Alzheimer's disease. Levels of A beta in cerebrospinal fluid were not significantly different among these groups. This observation suggests that concentrations of soluble A beta in cerebrospinal fluid as measured in this study do not reflect the amount of fibrillar, aggregated A beta in the brain of patients with Alzheimer's disease.
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