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  • Title: Proton magnetic resonance spectroscopic imaging in patients with frontal lobe epilepsy.
    Author: Garcia PA, Laxer KD, van der Grond J, Hugg JW, Matson GB, Weiner MW.
    Journal: Ann Neurol; 1995 Feb; 37(2):279-81. PubMed ID: 7847871.
    Abstract:
    Proton magnetic resonance spectroscopic imaging (1H MRSI) has demonstrated decreased N-acetyl compounds (NA) in the epileptogenic hippocampus in patients with temporal lobe epilepsy. We studied 8 patients with frontal lobe epilepsy and found mean NA/creatine (Cr) in the epileptogenic frontal lobe decreased by 27% compared with that of the contralateral homologous region (1.81 +/- 0.36 vs 2.49 +/- 0.60, p < 0.008). In every patient, NA/Cr was decreased in the epileptogenic region by at least 5%. These findings suggest that 1H MRSI may be useful in the presurgical evaluation of patients with frontal lobe epilepsy.
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