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  • Title: Eosinophil cationic protein and prophylactic treatment in pollinosis in natural allergen provocation.
    Author: Kato M, Hattori T, Takahashi M, Yanagita N, Nakashima I.
    Journal: Br J Clin Pract; 1994; 48(6):299-301. PubMed ID: 7848790.
    Abstract:
    In this study, prophylactic treatment with ketotifen and examination of subjective symptoms, blood eosinophil count and serum eosinophil cationic protein (ECP) values were carried out from the pre- to postpollinosis season to evaluate the effects of ECP and characterise the effects of prophylactic treatment on the appearance of these mediators in relation to clinical symptoms. We found that: serum ECP values during the season and post-season were significantly higher than those during the pre-season; there was a significant correlation between serum ECP value and blood eosinophil count during the season; and the levels for all three of the above parameters in the prophylactic treatment group were significantly lower than those in the no-treatment group during the season.
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