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  • Title: Metoclopramide decreases emesis after spinal anesthesia supplemented with subarachnoid morphine.
    Author: Knudsen K, Lisander B.
    Journal: Reg Anesth; 1994; 19(6):390-4. PubMed ID: 7848948.
    Abstract:
    BACKGROUND AND OBJECTIVES: The authors studied whether metoclopramide decreases the incidence of emesis after spinal anesthesia supplemented with subarachnoid morphine. METHODS: Patients underwent total hip arthroplasty under spinal anesthesia using tetracaine with norepinephrine and morphine 0.2 mg. Forty-eight patients were included in the study conducted with a paired design, using sequential analysis. Patients were allocated randomly and double-blinded to the treatment with metoclopramide or to the control group. In one group, metoclopramide 20 mg intramuscularly was given before and after surgery; patients in the control group were given equal volumes of saline. The presence of emesis for 5 hours postoperatively was recorded. RESULTS: In the postoperative period, emesis was noted in 58% of control patients but in only 17% of patients given metoclopramide (P < .05). CONCLUSIONS: The data suggest that metoclopramide is effective against postoperative emesis after spinal anesthesia supplemented with subarachnoid morphine.
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